منابع مشابه
Do HSCs divide asymmetrically?
Hematopoiesis is maintained by stem cells with the ability to both self-renew and to give rise to differentiated progeny. A proper balance between these fates is essential to prevent hematopoietic failure or uncontrolled stem cell expansion. So how do HSCs undergo self-renewal? In theory, this can occur in 2 ways; either through symmetrical cell division (SCD) where 2 new stem cells are formed,...
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T h e m e m b e r s of t h e S t u d e n t Ass o c i a t i o n , d e c k e d out in "BRO-wear," g a t h e r e d in t h e Farnsworth Pav i l ion Sept . 6 for s m o o t h i e s , b a c k s l a p s a n d s o m e t h i n g m o r e ser ious : d i s c u s s i o n of t h e S t u d e n t A d m i n i s t r a t i o n Relat i o n s R e s o l u t i o n . This r e s o l u t i o n w a s i n t r o d u c e d a...
متن کاملCotransplantation of MSCs and HSCs.
Apilot study by Wu et al. (1) suggests that umbilical cordYderived mesenchymal stem cells (UCMSCs) promote hematopoietic engraftment when cotransplanted with cord blood (CB) cells (Fig. 1A). The authors make good use of two somatic stem cells, both derived from umbilical cord. Together with the establishment of their UCMSC bank, their trial appears to be potentially meaningful for future develo...
متن کاملStem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.
Whether aged hematopoietic stem and progenitor cells (HSPCs) have impaired DNA damage repair is controversial. Using a combination of DNA mutation indicator assays, we observe a 2- to 3-fold increase in the number of DNA mutations in the hematopoietic system upon aging. Young and aged hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) do not show an increase in mutation u...
متن کاملTo eat or not to eat, that is the question...
Managing invasive species is a current challenge for biodiversity conservation. A recurring recent suggestion is that by harvesting nonnatives for human consumption, people can control invasive populations. Even though humans may be able to control or eradicate certain populations of nonnative species by harvesting them as food sources, several caveats should be considered before starting these...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2009
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri2627